TREML2

Across TCGA cell cohorts, TREML2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TREML2-associated genes across cancer lineages are POTED, MMP26, and GPR171. Each is linked with TREML2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREML2-to-partner and partner-to-TREML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTED grouped by TREML2-low versus TREML2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML2→partner) and Y-score (partner→TREML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POTED →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	GPR171 →	+0.017	+3.688	<.001	.002	3	1
LARGE_INTESTINE	FOXI2 →	+0.016	+3.632	<.001	.003	3	1
LARGE_INTESTINE	FAM205C →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GPX5 →	+0.266	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

POTED by TREML2 expression — LARGE_INTESTINE

Explore this box plot interactively →