TREM2

Across TCGA patient cohorts, TREM2 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,692 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TREM2-associated proteins across cancer lineages are LSP1, PLCB2, and APBB1IP. Each is linked with TREM2 in more than 7 cancer types. Because this analysis shows association rather than direction, both TREM2-to-partner and partner-to-TREM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TREM2 versus LSP1 in GBM, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TREM2→partner) and Y-score (partner→TREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LSP1 →	+0.986	+1.272	<.001	<.001	3	8
GBM	PLCB2 →	+0.599	+1.151	<.001	<.001	3	7
GBM	APBB1IP →	+0.751	+1.284	<.001	<.001	3	7
GBM	MSR1 →	+0.785	+1.126	<.001	<.001	3	7
CCRCC	MSR1_S27 →	+1.047	+1.264	<.001	<.001	3	7
GBM	PARVG →	+0.613	+1.089	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,692 associations by consensus.

TREM2 vs LSP1 — GBM

Explore this scatter interactively →