Across TCGA patient cohorts, TRDV1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRDV1-associated genes across cancer lineages are Fibronectin, JNK_pT183_Y185, and N-Ras. Each is linked with TRDV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRDV1-to-partner and partner-to-TRDV1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRDV1→partner) and Y-score (partner→TRDV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Fibronectin →	+0.476	+2.321	.033	.035	3	1
SKCM	JNK_pT183_Y185 →	+0.174	+2.321	.010	.035	3	1
SKCM	N-Ras →	+0.180	+3.000	.008	.034	3	1
SKCM	p90 RSK_pT359_S363 →	+0.214	+2.321	.011	.035	3	1
SKCM	PAI-1 →	+1.381	+3.000	<.001	.035	3	1
SKCM	PKC-b-II_pS660 →	-0.466	-3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TRDV1 survival (RNA) · tumor vs normal (RNA) · all TRDV1 data types