TRBV8-2

Across TCGA patient cohorts, TRBV8-2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,041 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TRBV8-2-associated proteins across cancer lineages are MKNK1_S221, ARPC1B, and SH3BP4_S246. Each is linked with TRBV8-2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRBV8-2-to-partner and partner-to-TRBV8-2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRBV8-2 versus MKNK1_S221 in PDAC, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV8-2→partner) and Y-score (partner→TRBV8-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MKNK1_S221 →	+0.766	+0.909	<.001	<.001	3	4
GBM	ARPC1B →	+0.427	+0.321	<.001	.001	3	3
CCRCC	SH3BP4_S246 →	-0.692	-0.626	<.001	<.001	3	3
OV	TFAM →	-0.667	-0.510	<.001	.001	3	3
COAD	TRPV2 →	+0.310	+0.280	<.001	.004	3	3
GBM	WIZ →	-0.311	-0.367	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,041 associations by consensus.

TRBV8-2 vs MKNK1_S221 — PDAC

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