TRBV8-2

Across TCGA pan-cancer cohorts, TRBV8-2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TRBV8-2 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRBV8-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRBV8-2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

UCEC, HNSC, and MESO are the cancer types where TRBV8-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.416	0.690	.004	72	view →
HNSC	OS	Median	III,IV	0.491	0.776	.001	47	view →
MESO	OS	Tertile	IV	0.201	0.721	.004	42	view →
CHOL	OS	Tertile	III,IV	0.162	0.915	.004	36	view →
BRCA	DFS	Median	III,IV	0.604	0.364	<.001	36	view →
SKCM	OS	Tertile	All	0.462	0.276	<.001	30	view →
LAML	DFS	Tertile	All	0.721	0.497	.008	26	view →
GBM	OS	Tertile	All	0.275	0.504	.002	22	view →
BLCA	DFS	Quartile	III,IV	0.305	0.543	.008	16	view →
READ	OS	Median	IV	0.995	0.541	.006	15	view →
KIRC	DFS	Quartile	IV	0.233	0.544	.023	12	view →
KIRP	DFS	Median	IV	0.041	0.523	.029	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TRBV8-2–UCEC (DFS)

Open the UCEC breakdown →