TRBV7-9

Across TCGA pan-cancer cohorts, TRBV7-9 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TRBV7-9 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV7-9 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV7-9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where TRBV7-9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.404	0.228	<.001	146	view →
SKCM	OS	Median	All	0.429	0.263	<.001	132	view →
CESC	DFS	Tertile	All	0.845	0.658	<.001	68	view →
UCEC	OS	Quartile	All	0.814	0.541	.003	66	view →
LIHC	DFS	Tertile	All	0.523	0.317	<.001	65	view →
BRCA	DFS	Tertile	All	0.572	0.494	.003	59	view →
LGG	OS	Tertile	All	0.837	0.928	<.001	41	view →
LUAD	DFS	Quartile	All	0.751	0.595	.002	39	view →
BLCA	OS	Tertile	IV	0.686	0.520	.015	33	view →
UVM	DFS	Quartile	II,III,IV	0.334	0.782	.002	28	view →
COAD	DFS	Median	All	0.746	0.641	.017	26	view →
OV	DFS	Quartile	All	0.446	0.345	.022	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TRBV7-9–HNSC (DFS)

Open the HNSC breakdown →