TRBV7-9

Across TCGA pan-cancer cohorts, TRBV7-9 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TRBV7-9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV7-9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV7-9 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where TRBV7-9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV7-9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.094	<.001	11	view →
COAD	All	All	−0.610	.002	7	view →
KICH	All	All	−0.599	.007	3	view →
PAAD	Female	All	−2.460	.044	2	view →
THCA	All	All	−0.655	.015	2	view →
BRCA	All	All	+0.328	.040	2	view →
LUSC	Male	III,IV	−1.172	.024	1	view →
STAD	All	All	+0.872	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TRBV7-9–KIRC

Open the KIRC breakdown →