TRBV7-7

Across TCGA pan-cancer cohorts, TRBV7-7 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRBV7-7 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRBV7-7 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRBV7-7 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

SKCM, UVM, and BRCA are the cancer types where TRBV7-7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.398	0.277	<.001	90	view →
UVM	OS	Tertile	II,III,IV	0.302	0.661	.003	66	view →
BRCA	OS	Median	II,III,IV	0.659	0.472	.001	48	view →
PAAD	DFS	Tertile	II,III,IV	0.411	0.245	.001	47	view →
OV	OS	Median	III,IV	0.366	0.270	.002	44	view →
CESC	OS	Tertile	All	0.901	0.739	.001	42	view →
HNSC	DFS	Quartile	All	0.787	0.658	.001	34	view →
KICH	DFS	Tertile	II,III,IV	0.432	0.880	.022	21	view →
CHOL	DFS	Quartile	All	0.767	0.267	.023	18	view →
LGG	OS	Tertile	All	0.258	0.496	.007	18	view →
THCA	DFS	Tertile	II,III,IV	0.945	0.536	.016	18	view →
LIHC	DFS	Tertile	All	0.697	0.508	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRBV7-7–SKCM (OS)

Open the SKCM breakdown →