TRBV7-7

Across TCGA pan-cancer cohorts, TRBV7-7 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRBV7-7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV7-7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV7-7 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

KIRC, BRCA, and STAD are the cancer types where TRBV7-7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV7-7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.431	<.001	9	view →
BRCA	All	II,III,IV	+0.142	.009	4	view →
STAD	Female	III,IV	+1.805	<.001	3	view →
LUAD	All	IV	−0.740	.041	2	view →
KICH	Female	All	−0.124	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TRBV7-7–KIRC

Open the KIRC breakdown →