TRBV6-8

Across TCGA pan-cancer cohorts, TRBV6-8 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRBV6-8 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TRBV6-8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRBV6-8 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRC show a favorable association.

BLCA, COAD, and KIRC are the cancer types where TRBV6-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	II,III,IV	0.612	0.335	.003	51	view →
COAD	DFS	Tertile	All	0.682	0.810	.011	48	view →
KIRC	DFS	Tertile	IV	0.798	0.189	.001	42	view →
LUSC	DFS	Tertile	II,III,IV	0.424	0.638	.001	42	view →
LGG	OS	Tertile	All	0.260	0.470	<.001	39	view →
UCEC	DFS	Tertile	All	0.828	0.910	.002	36	view →
LIHC	OS	Tertile	III,IV	0.051	0.650	<.001	36	view →
PRAD	DFS	Tertile	All	0.869	0.939	<.001	30	view →
SKCM	OS	Tertile	All	0.874	0.766	.013	27	view →
ESCA	OS	Tertile	All	0.620	0.411	.038	24	view →
THCA	DFS	Quartile	III,IV	0.983	0.860	.011	19	view →
THYM	OS	Median	All	1.000	0.717	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRBV6-8–BLCA (OS)

Open the BLCA breakdown →