TRBV6-8

Across TCGA pan-cancer cohorts, TRBV6-8 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TRBV6-8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRBV6-8 RNA is repressed in tumor relative to normal tissue. In most cancer types TRBV6-8 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where TRBV6-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV6-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.154	<.001	7	view →
KIRC	All	All	+0.048	.008	4	view →
LUAD	All	All	+0.083	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

TRBV6-8–COAD

Open the COAD breakdown →