TRBV6-7

Across TCGA pan-cancer cohorts, TRBV6-7 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRBV6-7’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where TRBV6-7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV6-7 is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.

STAD, KIRC, and READ are the cancer types where TRBV6-7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV6-7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Female	All	+0.385	<.001	4	view →
KIRC	Male	All	+0.074	<.001	4	view →
READ	All	III,IV	−0.610	.021	3	view →
COAD	All	All	−0.068	.019	3	view →
THCA	Male	All	+0.171	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TRBV6-7–STAD

Open the STAD breakdown →