TRBV6-1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRBV6-1 mutation is significantly associated with the RNA expression of many other genes, with 309 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRBV6-1-associated genes across cancer lineages are FAM106DP, OR2T33, and RPL23AP24. Each is linked with TRBV6-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV6-1-to-partner and partner-to-TRBV6-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV6-1→partner) and Y-score (partner→TRBV6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLCAFAM106DP →+0.142+5.106<.001.00832
LUSCOR2T33 →+0.106+5.371<.001<.00132
LUSCRPL23AP24 →+0.104+4.606<.001.00632
LUSCRNU6-826P →+0.617+4.204.001.00432
LUSCRNA5SP373 →+0.255+5.517<.001.00132
LUSCIGHVIII-38-1 →+1.879+3.832<.001.00932
Each partner links to its Q-omics profile. Showing the 6 strongest of 309 associations by consensus.

Exploration