Across TCGA pan-cancer cohorts, TRBV6-1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TRBV6-1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV6-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV6-1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.
KIRC, BLCA, and BRCA are the cancer types where TRBV6-1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV6-1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.