TRBV5-2

Across TCGA pan-cancer cohorts, TRBV5-2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated TRBV5-2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TRBV5-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRBV5-2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LAML show a favorable association.

KIRC, COAD, and LIHC are the cancer types where TRBV5-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.496	0.806	<.001	144	view →
COAD	DFS	Tertile	III,IV	0.258	0.675	.001	96	view →
LIHC	DFS	Tertile	All	0.078	0.559	<.001	63	view →
UCEC	DFS	Tertile	All	0.346	0.662	<.001	48	view →
TGCT	DFS	Tertile	II,III,IV	0.015	0.919	<.001	36	view →
PAAD	DFS	Tertile	II,III,IV	1.000	0.259	.009	18	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →
LAML	DFS	Quartile	All	0.725	0.512	.021	18	view →
LGG	OS	Tertile	All	0.988	0.880	.003	12	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
KIRP	OS	Tertile	All	0.590	0.903	.012	9	view →
THCA	OS	Tertile	IV	0.520	0.840	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

TRBV5-2–KIRC (OS)

Open the KIRC breakdown →