Across TCGA pan-cancer cohorts, TRBV4-1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRBV4-1 data layer compared with 22 for mass-spec protein.
The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRBV4-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRBV4-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.
LUAD, BLCA, and BRCA are the cancer types where TRBV4-1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.