Across TCGA pan-cancer cohorts, TRBV4-1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRBV4-1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV4-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV4-1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
KIRC, COAD, and UCEC are the cancer types where TRBV4-1 tumor–normal differential expression is most reproducible.