TRBV4-1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRBV4-1 mutation is significantly associated with the RNA expression of many other genes, with 1,128 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV4-1-associated genes across cancer lineages are RN7SL690P, RNU1-57P, and MPPE1. Each is linked with TRBV4-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV4-1-to-partner and partner-to-TRBV4-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV4-1→partner) and Y-score (partner→TRBV4-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMRN7SL690P →+0.081+3.356<.001.00532
BRCARNU1-57P →+0.562+7.731<.001.00932
UCECMPPE1 →+0.490+3.467.004.00232
SKCMTIPIN →+0.700+3.379.001.00532
BRCASNORD115-12 →+0.423+9.057<.001.00332
BRCARNU6-732P →+0.589+8.055<.001.00732
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,128 associations by consensus.

Exploration