TRBV4-1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRBV4-1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV4-1-associated genes across cancer lineages are INPP4B, MEK1, and p27_pT198. Each is linked with TRBV4-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV4-1-to-partner and partner-to-TRBV4-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV4-1→partner) and Y-score (partner→TRBV4-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECINPP4B →-0.320-2.999.049.03531
UCECMEK1 →+0.420+3.169.022.01931
UCECp27_pT198 →+0.116+2.321.030.03531
UCECPCNA →+0.215+2.321.047.03522
UCECBax →+0.259+2.321.031.03531
UCECTSC1 →-0.247-2.321.004.03521
Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

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