Across TCGA pan-cancer cohorts, TRBV23OR9-2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of TRBV23OR9-2’s most consistent transcriptional readouts.
The strongest signal is observed in prostate adenocarcinoma (PRAD), where TRBV23OR9-2 RNA is repressed in tumor relative to normal tissue. In most cancer types TRBV23OR9-2 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.
PRAD are the cancer types where TRBV23OR9-2 tumor–normal differential expression is most reproducible.