Across TCGA patient cohorts, TRBV21OR9-2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRBV21OR9-2-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and MIG-6. Each is linked with TRBV21OR9-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV21OR9-2-to-partner and partner-to-TRBV21OR9-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV21OR9-2→partner) and Y-score (partner→TRBV21OR9-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.272	-2.999	.038	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.130	-3.321	.046	.010	3	1
SKCM	MIG-6 →	+0.375	+2.832	<.001	.034	3	1
SKCM	Src_pY416 →	-0.378	-3.000	.032	.036	2	2
SKCM	Src →	-0.357	-3.000	.006	.036	3	1
SKCM	Bim →	-0.300	-3.000	.049	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TRBV21OR9-2 survival (RNA) · tumor vs normal (RNA) · all TRBV21OR9-2 data types