TRBV21-1

Across TCGA patient cohorts, TRBV21-1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV21-1-associated genes across cancer lineages are MS4A13, DPY19L4P2, and LINC02403. Each is linked with TRBV21-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV21-1-to-partner and partner-to-TRBV21-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A13 grouped by TRBV21-1-low versus TRBV21-1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV21-1→partner) and Y-score (partner→TRBV21-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MS4A13 →	+0.444	+5.283	<.001	.006	3	1
COAD	DPY19L4P2 →	+0.364	+5.017	<.001	.009	3	1
COAD	LINC02403 →	+0.382	+5.893	<.001	.002	3	1
UCEC	SSXP4 →	+0.129	+5.885	<.001	.001	3	1
UCEC	RNU6-776P →	+0.289	+4.868	<.001	.004	3	1
UCEC	RNY4P3 →	+0.476	+4.003	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MS4A13 by TRBV21-1 expression — COAD

Explore this box plot interactively →