TRBV21-1

Across TCGA pan-cancer cohorts, TRBV21-1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TRBV21-1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRBV21-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRBV21-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

SKCM, LUAD, and BRCA are the cancer types where TRBV21-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.434	0.278	<.001	83	view →
LUAD	OS	Tertile	All	0.765	0.633	.002	59	view →
BRCA	OS	Median	All	0.621	0.534	.002	57	view →
LGG	DFS	Tertile	All	0.561	0.849	<.001	54	view →
HNSC	DFS	Quartile	All	0.688	0.557	.003	42	view →
KICH	OS	Tertile	II,III,IV	0.826	0.957	.036	33	view →
PAAD	DFS	Median	II,III,IV	0.546	0.363	<.001	32	view →
KIRP	OS	Quartile	II,III,IV	0.295	0.620	.007	32	view →
STAD	DFS	Quartile	II,III,IV	0.569	0.224	.008	30	view →
THYM	OS	Median	II,III,IV	1.000	0.625	<.001	18	view →
MESO	DFS	Median	All	0.686	0.217	.001	18	view →
COAD	OS	Median	III,IV	0.685	0.451	.018	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TRBV21-1–SKCM (OS)

Open the SKCM breakdown →