TRBV15

Across TCGA pan-cancer cohorts, TRBV15 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRBV15 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV15 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UVM, and UCEC are the cancer types where TRBV15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.755	0.637	<.001	125	view →
UVM	DFS	Median	All	0.329	0.742	<.001	80	view →
UCEC	OS	Median	All	0.779	0.578	.005	68	view →
SKCM	OS	Tertile	All	0.500	0.261	<.001	60	view →
LUAD	OS	Quartile	III,IV	0.837	0.364	.001	46	view →
CESC	OS	Quartile	All	0.857	0.671	.003	46	view →
LGG	DFS	Tertile	All	0.733	0.852	<.001	36	view →
KIRC	DFS	Median	III,IV	0.643	0.293	<.001	32	view →
COAD	DFS	Quartile	II,III,IV	0.856	0.722	.004	32	view →
BLCA	OS	Quartile	III,IV	0.759	0.609	.007	31	view →
LIHC	OS	Median	All	0.846	0.722	.005	29	view →
READ	OS	Median	All	0.922	0.520	.004	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRBV15–HNSC (DFS)

Open the HNSC breakdown →