TRBV15

Across TCGA pan-cancer cohorts, TRBV15 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRBV15’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV15 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where TRBV15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.862	<.001	11	view →
BRCA	Female	II,III,IV	+0.282	<.001	4	view →
COAD	All	IV	−0.620	.002	3	view →
KIRP	All	IV	+0.280	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TRBV15–KIRC

Open the KIRC breakdown →