TRBV12-5

Across TCGA pan-cancer cohorts, TRBV12-5 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TRBV12-5 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV12-5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV12-5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and SKCM are the cancer types where TRBV12-5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.789	0.651	<.001	98	view →
LUAD	DFS	Median	All	0.737	0.593	<.001	97	view →
SKCM	OS	Median	All	0.424	0.283	<.001	84	view →
UVM	DFS	Tertile	All	0.338	0.613	.009	36	view →
LGG	OS	Tertile	All	0.762	0.911	<.001	33	view →
ACC	DFS	Tertile	III,IV	0.010	0.364	<.001	27	view →
KIRC	DFS	Tertile	All	0.748	0.850	.006	24	view →
CHOL	DFS	Median	All	0.694	0.242	.013	21	view →
LIHC	DFS	Tertile	All	0.431	0.217	.003	19	view →
LUSC	OS	Median	III,IV	0.696	0.359	<.001	18	view →
THYM	OS	Tertile	II,III,IV	1.000	0.649	.005	16	view →
BLCA	OS	Quartile	III,IV	0.739	0.624	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TRBV12-5–HNSC (DFS)

Open the HNSC breakdown →