TRBV12-5

Across TCGA pan-cancer cohorts, TRBV12-5 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRBV12-5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV12-5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV12-5 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where TRBV12-5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV12-5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.285	<.001	11	view →
COAD	Male	II,III,IV	−0.235	.021	2	view →
LUSC	All	All	−0.186	.010	2	view →
LIHC	Female	II,III,IV	+0.072	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TRBV12-5–KIRC

Open the KIRC breakdown →