TRBV12-3

Across TCGA pan-cancer cohorts, TRBV12-3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRBV12-3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV12-3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV12-3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and UVM are the cancer types where TRBV12-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.670	0.533	<.001	144	view →
UCEC	OS	Median	All	0.794	0.579	.001	100	view →
UVM	DFS	Tertile	II,III,IV	0.229	0.711	<.001	81	view →
SKCM	OS	Median	All	0.835	0.726	<.001	79	view →
CESC	OS	Tertile	All	0.885	0.704	<.001	64	view →
LUAD	DFS	Quartile	All	0.838	0.601	<.001	37	view →
BRCA	DFS	Quartile	All	0.639	0.470	.002	34	view →
LIHC	DFS	Median	II,III,IV	0.598	0.315	.001	32	view →
KICH	DFS	Quartile	II,III,IV	0.570	0.912	.005	23	view →
KIRC	DFS	Quartile	II,III,IV	0.716	0.342	.003	20	view →
READ	OS	Quartile	All	0.819	1.000	.015	20	view →
LGG	OS	Tertile	All	0.682	0.850	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRBV12-3–HNSC (DFS)

Open the HNSC breakdown →