TRBV12-3

Across TCGA pan-cancer cohorts, TRBV12-3 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TRBV12-3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV12-3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV12-3 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

KIRC, BRCA, and ESCA are the cancer types where TRBV12-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV12-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.102	<.001	11	view →
BRCA	All	III,IV	+0.331	.007	6	view →
ESCA	All	II,III,IV	+1.040	.005	2	view →
STAD	Female	All	+0.992	.038	2	view →
COAD	Female	III,IV	−0.484	.017	2	view →
LUAD	All	All	+0.308	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TRBV12-3–KIRC

Open the KIRC breakdown →