TRBV10-3

Across TCGA pan-cancer cohorts, TRBV10-3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRBV10-3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV10-3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV10-3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BLCA are the cancer types where TRBV10-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.674	0.532	<.001	141	view →
SKCM	OS	Median	All	0.838	0.721	<.001	102	view →
BLCA	DFS	Median	All	0.700	0.472	.001	96	view →
OV	OS	Median	All	0.390	0.270	.003	68	view →
LGG	OS	Tertile	All	0.798	0.928	<.001	48	view →
CESC	DFS	Tertile	All	0.799	0.628	.003	36	view →
LUAD	DFS	Tertile	All	0.761	0.603	<.001	36	view →
UCEC	OS	Median	III,IV	0.705	0.423	.010	30	view →
BRCA	DFS	Quartile	All	0.920	0.871	.013	21	view →
THYM	OS	Median	All	1.000	0.736	.001	17	view →
LIHC	DFS	Quartile	All	0.459	0.216	.003	17	view →
COAD	DFS	Tertile	IV	0.502	0.265	.011	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRBV10-3–HNSC (DFS)

Open the HNSC breakdown →