TRBV10-3

Across TCGA pan-cancer cohorts, TRBV10-3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TRBV10-3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV10-3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV10-3 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KIRC, LUSC, and COAD are the cancer types where TRBV10-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV10-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.075	<.001	10	view →
LUSC	Male	III,IV	−0.917	.003	5	view →
COAD	All	II,III,IV	−0.425	.013	4	view →
BRCA	All	All	+0.302	.013	4	view →
PAAD	Female	All	−3.270	.006	2	view →
THCA	All	All	−0.456	.037	1	view →
HNSC	Female	All	+0.449	.045	1	view →
LUAD	Female	All	+0.440	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TRBV10-3–KIRC

Open the KIRC breakdown →