Across TCGA patient cohorts, TRAV26-1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAV26-1-associated genes across cancer lineages are EGFR_pY1173, ERK2, and FOXO3a_pS318_S321. Each is linked with TRAV26-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV26-1-to-partner and partner-to-TRAV26-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV26-1→partner) and Y-score (partner→TRAV26-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.092	+2.348	.021	.019	3	1
UCEC	ERK2 →	+0.280	+2.321	.003	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.201	-3.312	.001	.010	3	1
UCEC	GSK-3_pS9 →	-0.771	-2.321	<.001	.035	3	1
UCEC	Ku80 →	+0.275	+2.335	.020	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.726	-3.169	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

TRAV26-1 survival (RNA) · tumor vs normal (RNA) · all TRAV26-1 data types