Across TCGA pan-cancer cohorts, TRAV25 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TRAV25 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRAV25 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRAV25 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUAD, LUSC, and PRAD are the cancer types where TRAV25 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.074	0.712	<.001	30	view →
LUSC	OS	Median	All	0.056	0.776	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	III,IV	1.000	0.491	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRAV25 tumor-vs-normal RNA expression · all TRAV25 data types