Across TCGA pan-cancer cohorts, TRAV25 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TRAV25’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAV25 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAV25 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.
KIRC, BRCA, and COAD are the cancer types where TRAV25 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAV25 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.