Across TCGA patient cohorts, TRAV12-2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAV12-2-associated genes across cancer lineages are EGFR, A-Raf_pS299, and MEK1. Each is linked with TRAV12-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV12-2-to-partner and partner-to-TRAV12-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV12-2→partner) and Y-score (partner→TRAV12-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.202	-2.321	.011	.035	3	1
UCEC	A-Raf_pS299 →	-0.165	-2.999	.006	.035	3	1
UCEC	MEK1 →	+0.554	+3.459	.002	.005	3	1
UCEC	Notch1 →	+0.297	+2.331	<.001	.019	3	1
UCEC	AR →	-0.419	-2.321	.025	.035	3	1
UCEC	TFRC →	+0.988	+3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

TRAV12-2 survival (RNA) · tumor vs normal (RNA) · all TRAV12-2 data types