TRAV1-2

Across TCGA patient cohorts, TRAV1-2 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRAV1-2-associated genes across cancer lineages are RNU6-905P, RNU6ATAC29P, and RN7SKP228. Each is linked with TRAV1-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV1-2-to-partner and partner-to-TRAV1-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-905P grouped by TRAV1-2-low versus TRAV1-2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV1-2→partner) and Y-score (partner→TRAV1-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-905P →	+0.433	+6.098	<.001	<.001	3	2
SKCM	RNU6ATAC29P →	+0.272	+5.080	<.001	.004	3	2
SKCM	RN7SKP228 →	+0.142	+4.970	<.001	.005	3	2
UCEC	RAX →	+0.373	+3.677	.002	.007	3	1
SKCM	NEURL1-AS1 →	+0.147	+4.867	<.001	.005	3	1
SKCM	OFD1P11Y →	+0.037	+7.816	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

RNU6-905P by TRAV1-2 expression — SKCM

Explore this box plot interactively →