TRAPPC3L

Across TCGA patient cohorts, TRAPPC3L mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC3L-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and JNK2. Each is linked with TRAPPC3L in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC3L-to-partner and partner-to-TRAPPC3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRAPPC3L-low versus TRAPPC3L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC3L→partner) and Y-score (partner→TRAPPC3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.693	-3.000	.003	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.258	-3.308	.003	.010	3	1
UCEC	JNK2 →	+0.334	+3.321	.001	.010	3	1
UCEC	Akt_pS473 →	+0.947	+3.000	.011	.036	3	1
UCEC	Akt_pT308 →	+0.793	+3.000	.016	.036	3	1
UCEC	PRAS40_pT246 →	+0.227	+2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ATM by TRAPPC3L expression — UCEC

Explore this box plot interactively →