TRAPPC2L

Across TCGA patient cohorts, TRAPPC2L mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC2L-associated genes across cancer lineages are Heregulin, MSH6, and Rab11. Each is linked with TRAPPC2L in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC2L-to-partner and partner-to-TRAPPC2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by TRAPPC2L-low versus TRAPPC2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC2L→partner) and Y-score (partner→TRAPPC2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.127	-2.222	.015	.011	3	1
UCEC	MSH6 →	-0.406	-1.700	.003	.044	3	1
UCEC	Rab11 →	-0.123	-2.906	.045	.001	3	1
UCEC	ATM →	-0.541	-2.308	.004	.033	3	1
UCEC	ERK2 →	+0.178	+2.459	.029	.019	2	1
UCEC	MSH2 →	-0.316	-3.312	.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Heregulin by TRAPPC2L expression — UCEC

Explore this box plot interactively →