TRAPPC13

Across TCGA cell cohorts, TRAPPC13 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAPPC13-associated genes across cancer lineages are SPHKAP, GRIK1, and PNMA6F. Each is linked with TRAPPC13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC13-to-partner and partner-to-TRAPPC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPHKAP grouped by TRAPPC13-low versus TRAPPC13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC13→partner) and Y-score (partner→TRAPPC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPHKAP →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GRIK1 →	+0.044	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PNMA6F →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ADGRA1 →	+0.038	+4.237	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SPHKAP by TRAPPC13 expression — LARGE_INTESTINE

Explore this box plot interactively →