TRAM2

Across TCGA patient cohorts, TRAM2 mutation is significantly associated with the RNA expression of many other genes, with 2,035 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAM2-associated genes across cancer lineages are RNA5SP422, RNA5SP420, and MIR6803. Each is linked with TRAM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAM2-to-partner and partner-to-TRAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by TRAM2-low versus TRAM2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAM2→partner) and Y-score (partner→TRAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP422 →	+0.804	+5.733	<.001	.001	3	3
LUSC	RNA5SP420 →	+0.523	+5.309	.001	.003	3	2
UCEC	MIR6803 →	+0.082	+3.893	<.001	.006	3	2
UCEC	BNIP3P6 →	+0.021	+3.893	<.001	.006	3	2
SKCM	FABP3P2 →	+0.114	+6.080	<.001	.002	3	2
BRCA	MIR6737 →	+0.678	+5.506	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,035 associations by consensus.

RNA5SP422 by TRAM2 expression — LUSC

Explore this box plot interactively →