TRAK2

Across TCGA patient cohorts, TRAK2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAK2-associated genes across cancer lineages are ATM, EGFR_pY1068, and p38-MAPK_pT180_Y182. Each is linked with TRAK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAK2-to-partner and partner-to-TRAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRAK2-low versus TRAK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAK2→partner) and Y-score (partner→TRAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.560	-1.584	<.001	.019	3	3
UCEC	EGFR_pY1068 →	-0.243	-1.925	.007	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.412	-1.584	.010	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.494	+2.604	.020	.005	3	2
COAD	ASNS →	+0.770	+3.008	<.001	.019	3	1
UCEC	eIF4E →	+0.150	+1.584	.048	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by TRAK2 expression — UCEC

Explore this box plot interactively →