TRAK2

Across TCGA pan-cancer cohorts, TRAK2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRAK2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TRAK2 RNA is repressed in tumor relative to normal tissue. In most cancer types TRAK2 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and LUSC are the cancer types where TRAK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.097	<.001	10	view →
COAD	Female	All	−0.999	<.001	10	view →
LUSC	Female	II,III,IV	−1.215	<.001	9	view →
BLCA	All	All	−0.766	.007	8	view →
LIHC	Female	II,III,IV	+0.960	<.001	7	view →
KIRC	Male	II,III,IV	−0.479	<.001	6	view →
READ	All	All	−1.004	<.001	5	view →
PAAD	Female	All	−0.759	.024	4	view →
KICH	All	All	−0.574	<.001	4	view →
CHOL	All	All	+2.190	<.001	3	view →
THCA	All	All	+0.372	.006	3	view →
UCEC	All	All	−0.423	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRAK2–LUAD

Open the LUAD breakdown →