TRAK1

Across TCGA patient cohorts, TRAK1 mutation is significantly associated with the RNA expression of many other genes, with 3,892 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAK1-associated genes across cancer lineages are UBE2T, GMNN, and H2AZ1. Each is linked with TRAK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRAK1-to-partner and partner-to-TRAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2T grouped by TRAK1-low versus TRAK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAK1→partner) and Y-score (partner→TRAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2T →	+0.454	+1.315	.005	.005	3	5
UCEC	GMNN →	+0.514	+3.000	<.001	<.001	3	5
UCEC	H2AZ1 →	+0.513	+1.664	<.001	<.001	3	4
UCEC	PUSL1 →	+0.468	+1.642	<.001	<.001	3	4
UCEC	NCAPH2 →	+0.568	+2.280	<.001	<.001	3	4
UCEC	RFC2 →	+0.371	+1.675	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,892 associations by consensus.

UBE2T by TRAK1 expression — UCEC

Explore this box plot interactively →