TRAK1

Across TCGA pan-cancer cohorts, TRAK1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TRAK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAK1 RNA is repressed in tumor relative to normal tissue. In most cancer types TRAK1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where TRAK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.780	<.001	7	view →
COAD	Female	IV	−1.140	.001	6	view →
LIHC	Female	II,III,IV	+1.055	<.001	6	view →
CHOL	Male	All	+1.790	<.001	5	view →
STAD	Male	All	+0.742	.003	4	view →
HNSC	All	All	−0.381	.005	4	view →
THCA	All	All	−0.304	.002	4	view →
BRCA	Female	II,III,IV	−0.293	<.001	4	view →
KICH	All	All	+0.406	.008	3	view →
PAAD	All	All	+0.757	.019	2	view →
UCEC	All	III,IV	+0.676	.025	2	view →
LUAD	Female	All	−0.375	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TRAK1–KIRC

Open the KIRC breakdown →