TRAK1

Across TCGA patient cohorts, TRAK1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAK1-associated genes across cancer lineages are Rictor_pT1135, PCNA, and TFRC. Each is linked with TRAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAK1-to-partner and partner-to-TRAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by TRAK1-low versus TRAK1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAK1→partner) and Y-score (partner→TRAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Rictor_pT1135 →	-0.168	-2.321	.015	.034	3	3
COAD	PCNA →	+0.327	+2.467	.002	.011	3	3
UCEC	TFRC →	+0.454	+2.222	.004	.009	3	3
UCEC	ASNS →	+0.325	+1.440	.002	.022	3	3
UCEC	EGFR_pY1068 →	-0.243	-1.754	.001	.001	3	2
UCEC	GAPDH →	+0.421	+1.678	.009	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Rictor_pT1135 by TRAK1 expression — STAD

Explore this box plot interactively →