TRAK1

Across TCGA cell cohorts, TRAK1 mutation is significantly associated with the RNA expression of many other genes, with 847 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAK1-associated genes across cancer lineages are UCMA, CCL11, and CHRNB3. Each is linked with TRAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAK1-to-partner and partner-to-TRAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCMA grouped by TRAK1-low versus TRAK1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAK1→partner) and Y-score (partner→TRAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UCMA →	+0.165	+4.169	<.001	.008	3	3
LUNG_NSCLC_LUSC	CCL11 →	+0.270	+4.584	.004	.001	3	2
SKIN	CHRNB3 →	+0.006	+4.467	.007	.004	3	2
CNS	ASB10 →	+0.039	+4.566	<.001	.001	3	2
LARGE_INTESTINE	LRRC3C →	+0.162	+2.000	.008	.005	3	2
LUNG_NSCLC_LUAD	CABP5 →	+0.331	+4.481	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 847 associations by consensus.

UCMA by TRAK1 expression — CNS

Explore this box plot interactively →