Across TCGA pan-cancer cohorts, TRAJ8 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRAJ8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ8 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, STAD, and BRCA are the cancer types where TRAJ8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.184	.002	6	view →
STAD	All	II,III,IV	+0.437	.022	4	view →
BRCA	All	II,III,IV	+0.257	.012	4	view →
BLCA	All	III,IV	+0.367	.036	3	view →
THCA	All	All	−0.246	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRAJ8 RNA expression & survival · all TRAJ8 data types