Across TCGA pan-cancer cohorts, TRAJ6 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TRAJ6 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRAJ6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRAJ6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, DLBC, and HNSC are the cancer types where TRAJ6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	IV	0.829	0.308	.002	72	view →
DLBC	DFS	Tertile	III,IV	0.074	0.984	.003	49	view →
HNSC	DFS	Tertile	All	0.787	0.666	.004	48	view →
LGG	OS	Tertile	All	0.608	0.820	.001	33	view →
SKCM	DFS	Quartile	All	0.775	0.577	.003	33	view →
CHOL	DFS	Tertile	All	0.876	0.261	.003	24	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	18	view →
THYM	OS	Tertile	IV	0.294	1.000	.025	18	view →
MESO	OS	Tertile	IV	0.384	0.634	.023	18	view →
ESCA	DFS	Quartile	III,IV	0.524	0.265	.021	16	view →
STAD	DFS	Median	IV	0.137	0.500	.007	12	view →
KIRP	DFS	Tertile	All	0.518	0.810	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

Exploration

Same gene, other analysis: TRAJ6 tumor-vs-normal RNA expression · all TRAJ6 data types