Across TCGA pan-cancer cohorts, TRAJ6 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRAJ6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ6 is over-expressed in tumor, although a few such as LUSC and READ show the opposite, repressed pattern.

KIRC, LUSC, and READ are the cancer types where TRAJ6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.429	<.001	8	view →
LUSC	Male	III,IV	−1.224	.001	4	view →
READ	All	III,IV	−1.240	.010	3	view →
LUAD	Male	All	+1.033	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRAJ6 RNA expression & survival · all TRAJ6 data types