Across TCGA pan-cancer cohorts, TRAJ55 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TRAJ55’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where TRAJ55 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ55 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
LUAD and THCA are the cancer types where TRAJ55 tumor–normal differential expression is most reproducible.